Philipp Leucht, MD
Associate Professor, Orthopaedic Surgery and Cell Biology
Dr. Leucht received his medical degree in 2002 at the Ruhr-University Bochum, Germany. He then started an orthopaedic residency at the Johann-Wolfgang-Goethe University in Frankfurt am Main, Germany. Dr. Leucht started his clinician-scientist career in 2004, when he joined the laboratory of Dr. Jill Helms at Stanford University. He concentrated his research efforts on three major areas:
The cellular and molecular mechanisms that govern skeletal development and adult fracture healing
The effect of mechanical stimulation on bone regeneration
Stem-cell based tissue engineering strategies to enhance bone regeneration
our team
KEVIN LeClerc, Phd
Post-Doctorate Fellow, Department of Orthopedic Surgery
Hailing from Miami, Kevin developed a keen interest in embryonic development and regenerative biology during his undergraduate studies at the University of Pennsylvania in Philadelphia. He went on to complete a Ph.D. in Genetics and Development Columbia University studying kidney development, where a particular interest in cell fate specification solidified. He now investigates the influence of the positional memory of skeletal stem cells on bone regeneration. His interests outside the lab include traveling unbeaten paths, urban photography, linguistics, and dancing.
Sophie Morgani, PHD
Senior Research Scientist, Department of Orthopedic Surgery
Sophie is originally from the UK. She completed her PhD in the lab of Prof. Joshua Brickman at the University of Edinburgh (UK) and the Danish Stem Cell Centre (Copenhagen, Denmark), where she determined how signals drive the early pluripotent cells of the embryo to make one cell type versus another. Following on from this, she did a joint post-doc in the labs of Prof. Anna-Katerina Hadjantonakis, in the Developmental Biology Program, Memorial Sloan Kettering Cancer Center (NY, USA), and Prof. Jennifer Nichols, at the Wellcome-MRC Cambridge Stem Cell Institute, Cambridge University (UK). During this time, she established in vitro organoid systems and transgenic mouse lines to study not only how different cell types are made, but also how they are simultaneously patterned into functional tissues. Currently, in the Leucht lab, she is investigating how skeletal progenitor cell fate decisions of the are altered during aging and how this contributes to bone degeneration.
Margaux Sambon, PhD
Post-Doctoral Fellow, Department of Orthopedic Surgery
Margaux obtained her PhD in biomedical and pharmaceutical sciences at the University of Liège, Belgium. During her thesis in the laboratory of Pr. Lucien Bettendorff, she studied the antioxidant and anti-inflammatory effect of dibenzoylthiamine, a synthetic precursor of vitamin B1. She joined the laboratory in May 2022 after a post-doc at Mount Sinai in Neurosciences. Margaux studies the signaling pathways responsible for aging and which can serve as a target for better bone healing. When she's not in the lab, she enjoys exploring New York, hiking, discovering new museums or cafes.
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